Stem Cell Therapy Neurodegenerative Disease

Parkinson’s Disease The majority of complications in Parkinson’s patients are related to the failure of dopamine neurons to do their job properly. Dopamine sends signals to the part of your brain that controls movement. It lets your muscles move smoothly and do what you want them to do. Once the nerve cells break down you no longer have enough dopamine, and you have trouble moving and completing tasks. Stem cell therapy is designed to target these neurons and to help with the creation of new dopamine producing neurons. In addition, stem cells may release natural chemicals called cytokines which can induce differentiation of the stem cells into dopamine producing neurons. Patients who receive stem cell therapy may report improvements in one or more disease related complications such as:
  • Resting Tremor: – Slight tremor or shaking  in the hand or foot on one side of the body, or in the jaw or face and usually appears when a person’s muscles are relaxed, or at rest (not performing an action).
  • Bradykinesia: –  A general reduction of spontaneous movement, which can give the appearance of abnormal stillness and a decrease in facial expression. Causes difficulty with repetitive movements and performing everyday functions, such as buttoning a shirt, cutting food or brushing teeth, walking with short, shuffling steps, affect on ones speech; quieter and less distinct, drooling and excess saliva result from reduced swallowing movements.
  • Rigidity: – Rigidity causes stiffness and inflexibility of the limbs, neck and trunk. The muscle tone of an affected limb is always stiff and does not relax, sometimes contributing to a decreased range of motion. Rigidity can be uncomfortable or even painful and inhibits the swinging of arms when walking.
  • Postural Instability: – Postural Instability (a tendency to be unstable when standing upright) is caused by uncontrollable reflexes needed for maintaining an upright posture that can cause particular difficulty when pivoting or making turns or quick movements. It can also cause retropulsion (a dangerous tendency to sway backwards when rising from a chair, standing or turning).
Alzheimer’s disease Today, new treatments and advances in research are giving hope to people affected by this Alzheimer’s disease. The Alzheimer’s Stem Cell Studies are being studied for their efficacy in improving the complications in patients with Alzheimer’s, through the use of stem cells. These procedures may help patients who don’t respond to typical drug treatment. In order to perform at its greatest potential, our brains require coordination. With each group of cells in control of a certain bodily function, they act like tiny factories, carrying out each task in a routine manner. In a patient with AD, this signal flow is interrupted by progressive damage. Scientists believe that Alzheimer’s Disease prevents parts of the dense-branching communication network from running smoothly. The damage ultimately spreads to other parts of the brain causing irreversible damage and leading to the various symptoms associated with AD. People suffering from Alzheimer’s Disease often suffer from the following symptoms:
  • Memory loss
  • Difficulty completing normal tasks
  • Difficulty with interpretation of visual information
  • Reduced judgement
  • Inability to speak or write
  • Change in mood
  How can stem cell therapy help these conditions? Stem Cell Therapy Neurodegenerative Disease – Stem cells are well known for their ability to differentiate into multiple tissue types and have immune modulatory properties. It is also hoped that eventually stem cells might assist in rebuilding lost nerve fibers. This could repair the damage caused in the progressive stages of these diseases that results in the accumulation of disability. Scientists around the world agree that more research is much needed in this complicated and challenging area.

At DermaMed we use a combination of two injection methods for our patients diagnosed with these conditions: intravenous and lumbar puncture.

IV Infusion: Based on the clinical data and research stem cells may cross the blood-brain-barrier when injected systemically. The Intravenous (IV) infusion (drip) delivery method is a very simple process and should already be familiar to most patients. A catheter tip threaded over a needle is placed into the patient’s vein. Once proper placement is obtained, the needle portion is removed and the flexible plastic catheter is left in place in the vein with the tubing attached. The stem cell solution  will be administered through the IV. The entire IV injection process takes less than 30 minutes to complete.

Lumbar Puncture: also commonly referred to as a spinal tap. It is a procedure used to access the cerebrospinal fluid of the brain and spinal cord and helps to deliver stem cells directly into the cerebral spinal fluid, bypassing the blood-brain barrier. Our doctors have determined that this is the most effective method for delivering stem cells directly into the central nervous system. Cerebrospinal Fluid (CSF) is used by the body to provide protection for the brain and spinal cord, limiting the possibility of injury to these areas. The body constantly produces CSF and thus any withdrawn fluid is naturally replaced within a few hours.

Stem cell therapy may be repeated. Current studies indicate the strong possibility of a cumulative effect from multiple stem cell therapies a patient received for their condition. It is important to remember that the treatment is not a cure. Both these conditions are progressive and the aim of the treatment is to temporarily reverse the disease symptoms to achieve better quality of life.

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